Effect of ulinastain on the expression of hemeoxygenase-1 in oleic acid-induced acute lung injury in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 675-678, 2007.
Article
in Zh
| WPRIM
| ID: wpr-813818
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the effect of ulinastain on the expression of hemeoxy genase-1 (HO-1) in oil acid-induced acute lung injury in rats.@*METHODS@#The animal model of acute lung injury was established by oil acid. Thirty SD rats were randomly divided into 3 groups the blank control group (A), the acute lung injury group (B) and the acute lung injury group (C) followed by injecting 100 mL/kg ulinastatin. Each group consisted of 10 rats. Group A were given 0.2 mL/kg natural solution through the trial vein; Group B and C were given 0.2 mL/kg oil-acid through trial vein, while group C were injected 100mL/kg ulinastatin by the peritoneal cavity after injecting oil acid. After 4 hours, the rates of respiration were counted and blood samples were cramped out through the heart puncture for blood gas analysis. The expressions of hemeoxygenase-1 and the pathologic construction changes were determined by HE staining in the lower right lung of rats in the 3 groups.@*RESULTS@#The respiration dysfunction caused by oil acid could be prominently improved by ulinastain. There was only a little expression of hemeoxygenase-1 in the lung of Group A, but the expression increased in Group B and significatively increased in Group C.@*CONCLUSION@#Ulinastatin may protect the rats from acute lung injury through increasing the expression of HO-1.
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
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Glycoproteins
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Rats, Sprague-Dawley
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Oleic Acid
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Acute Lung Injury
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Heme Oxygenase (Decyclizing)
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Lung
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Metabolism
Limits:
Animals
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Document type:
Article